Association of polymorphisms in GAD1 and GAD2 genes with methamphetamine dependence

作者：Veerasakul Siriluk; Watiktinkorn Paritat; Thanoi Samur; Reynolds Gavin P; Nudmamud Thanoi Sutisa^*

来源：Pharmacogenomics, 2017, 18(1): 17-22.

DOI：10.2217/pgs-2016-0101

• GABAergic system
• glutamic acid decarboxylase
• methamphetamine
• SNP
• substance dependence

Aim: Association between polymorphisms in GAD genes and methamphetamine (METH) dependence was investigated in the Thai population. Materials & methods: Genotypes of rs769404 and rs701492 in GAD1 and rs2236418 in GAD2 polymorphisms were determined in 100 METH-dependent male subjects and 102 matched controls. Results: The genotype and allele frequencies of rs2236418 (GAD2) were associated with METH dependence and METH with psychosis, in which the G allele was related to increased risk. The presence of the rs769404-rs701492 (GAD1) C-C haplotype was associated with METH psychosis. Conclusion: This study indicates that genetic variability in GAD1 and GAD2 contributes to risk of METH dependence and METH psychosis in the Thai population and indicates the role of the GABAergic system in these disorders.

• 出版日期2017-1