A new diterpene from the leaves of Andrographis paniculata Nees

作者：Xu, Chong; Chou, Gui Xin; Wang, Zheng Tao^*

来源：Fitoterapia, 2010, 81(6): 610-613.

DOI：10.1016/j.fitote.2010.03.003

• Andrographis paniculata
• ent-labdane diterpenoids
• X-ray crystallographic analyses

Phytochemical investigation of the ethanol extract of the leaves of Andrographis paniculata yielded one novel diterpene (13R, 14R) 3, 13, 14, 19-tetrahydroxy-ent-labda-8 (17), 11-dien-16, 15-olide 1 which has an uncommon cis-diol groups in the lactone moiety, and 3, 19-isopropylidene-14-deoxy-ent-labda-8 (17), 13-dien-16, 15-olide 2, probably an artifact diterpene, together with eight known diterpenoids 3-10. The structures of these compounds were determined on the basis of spectral methods. The structure and stereochemistry of 1 was confirmed by X-ray crystallographic analyses.

• 出版日期2010-9
• 单位上海中药标准化研究中心; 上海中医药大学