Netrin-1 improves the amyloid-beta-mediated suppression of memory and synaptic plasticity

作者：Shabani Mohammad; Haghani Masoud^*; Tazangi Parisa Esmaeili; Bayat Mahnaz; Moosavi Seyed Mostafa Shid; Ranjbar Hoda

来源：Brain Research Bulletin, 2017, 131: 107-116.

DOI：10.1016/j.brainresbull.2017.03.015

• Beta amyloid
• Netrin-1
• Long-term potentiation
• Alzheimer's disease

The aim of this study was to investigate the effects of netrin-1 (NT-1) on amyloid-beta (A(3) induced impairments in learning-memory and synaptic plasticity.
The NT-1 or its vehicle was administered four times into the A beta+ NT or A beta 3 + V groups, respectively. The A beta+ SNT group received a single dose of NT-1. The A beta+ HNT group received heat-inactivated NT-1. For the learning-memory and synaptic plasticity assessment, field potentials recording and behavioral experiment were used.
Bilateral injection of A beta(1-42) inhibits induction of long-term potentiation (LTP) and decreased memory performance in all the behavioral tasks. However, only by repeated injection of NT-1, significant recovery of LTP and memory was seen. Although, the delivery of HFS to A beta+ NT group recovered EPSP slope of the maintenance phase when compared with A beta + V, but it failed to recover the induction phase.
It can be assumed that NT-1 may have regulatory effects on the synthesis of key proteins and/or structural changes that are responsible for LTP induction, since the protein synthesis and/or structural changes are required for the maintenance phase of LTP.

• 出版日期2017-5