Diabetes mellitus negatively affects peri-implant bone formation in the diabetic domestic pig

作者：von Wilmowsky Cornelius^*; Stockmann Philipp; Harsch Igor; Amann Kerstin; Metzler Philipp; Lutz Rainer; Moest Tobias; Neukam Friedrich Wilhelm; Schlegel Karl Andreas

来源：Journal of Clinical Periodontology, 2011, 38(8): 771-779.

DOI：10.1111/j.1600-051X.2011.01746.x

• bone
• diabetes
• implants
• osseointegration
• pig

Aim: Diabetes mellitus is classified as a relative contraindication for implant treatment, and higher failure rates have been seen in diabetic patients. The aim of the present study was to investigate the effect of diabetes on peri-implant bone formation in an animal model of human bone repair.
Materials and Methods: Diabetes was induced by an intra-venous application of streptozotocin (90 mg/kg) in 15 domestic pigs. Implants were placed after significant histopathological changes in the hard and soft tissues were verified. The bone-implant contact (BIC), peri-implant bone mineral density (BMD), and expression of collagen type-I and osteocalcin proteins were qualitatively evaluated 4 and 12 weeks after implantation. Fifteen animals served as healthy controls.
Results: Diabetes caused pathological changes in the soft and hard tissues. The BIC and BMD were significantly reduced in the diabetic group after 4 and 12 weeks. Collagen type-I was increased in the diabetic group at both time points, whereas osteocalcin was reduced in the diabetic group.
Conclusions: Poorly controlled diabetes negatively affects peri-implant bone formation and bone mineralization. These findings have to be taken into consideration for diabetic patients with an indication for implant therapy.

• 出版日期2011-8