A Versatile Approach to beta-Amyloid Fibril-Binding Compounds Exploiting the Shirakawa/Hayashi Protocol for trans-Alkene Synthesis

作者：Huynh Tri H V; Mantel Mette Louise H; Mikkelsen Katrine; Lindhardt Anders T; Nielsen Niels Chr; Otzen Daniel; Skrydstrup Troels^*

来源：Organic Letters, 2009, 11(4): 999-1002.

DOI：10.1021/ol8029593

Application of the Sonogashira coupling reaction followed by a trans-selective alkyne reduction proved highly adaptable for the efficient synthesis of a class of beta-amyloid fibril binding compounds possessing a styrylbenzene motif such as FSB, an FSB dimer, and (19)F-BAY94-9172.

• 出版日期2009-2-19