Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity

作者：Wang, Hangxiang^*; Wu, Jiaping; Xu, Li; Xie, Ke; Chen, Chao; Dong, Yuehan^*

来源：Chemical communications, 2017, 53(17): 2618-2621.

DOI：10.1039/c6cc08978j

• HUMAN SERUM-ALBUMIN
• IN-VIVO
• ANTITUMOR EFFICACY
• RATIONAL DESIGN
• THERAPY
• DELIVERY
• PRODRUGS
• COMBINATION
• TUMORS
• CHEMOTHERAPY

We here provide the first report on the construction of nanoparticles formulating highly potent cytotoxic therapeutics using albumin. Maytansinoid DM1 can be efficiently integrated into albumin nanoparticles, resulting in remarkable alleviation of in vivo drug toxicity and expanding the repertoire of albumin technology available for cancer therapy.

• 出版日期2017-2-28
• 单位浙江经贸职业技术学院; 浙江大学