科研之友
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摘要
In this paper, the acute toxicity of tetrabutylammonium chloride was approached through the 24 hours acute toxicity test, the major morphological changes induced in liver and kidney and the way in which this ionic liquid affects the catalase activity in mice. The results of our study show that average lethal concentration (LC50) in 24 h for the tetrabutylammonium chloride in mouse is 125 mg/Kg body weight. The histological observations proved that the acute exposure to the tetrabutylammonium chloride induces a series of histological changes both in liver and in kidney. The microscopic analysis of histological sections showed hypertrophies and hepatocyte vacuolations, glomerular compressions, thickening of the external layer of the Bowman'capsule, nephrocyte vacuolations as well as hypertrophies of the peri-tubular capillary network. The results of this study have also revealed a decrease in catalase activity, this process being more intense in individuals of the first two experimental groups.
- 出版日期2014-2
