NON-INVASIVE INTRA-CARDIAC PRESSURE MEASUREMENTS USING SUBHARMONIC-AIDED PRESSURE ESTIMATION: PROOF OF CONCEPT IN HUMANS

作者：Dave Jaydev K^*; Kulkarni Sushmita V; Pangaonkar Purva P; Stanczak Maria; McDonald Maureen E; Cohen Ira S; Mehrotra Praveen; Savage Michael P; Walinsky Paul; Ruggiero Nicholas J II; Fischman David L; Ogilby David; VanWhy Carolyn; Lombardii Matthew; For**erg Flemming

来源：Ultrasound in Medicine and Biology, 2017, 43(11): 2718-2724.

DOI：10.1016/j.ultrasmedbio.2017.07.009

• Subharmonic-aided pressure estimation
• Non-invasive pressure estimation
• Intra-cardiac pressures
• Ultrasound contrast agents
• Cardiac catheterization

This study evaluated the feasibility of employing non-invasive intra-cardiac pressure estimation using subharmonic signals from ultrasound contrast agents in humans. This institutional review board-approved proofof- concept study included 15 consenting patients scheduled for left and right heart catheterization. During the catheterization procedure, Definity was infused intra-venously at 4-10 mL/min. Ultrasound scanning was performed with a Sonix RP using pulse inversion, three incident acoustic output levels and 2.5-MHz transmit frequency. Radiofrequency data were processed and subharmonic amplitudes were compared with the pressure catheter data. The correlation coefficient between subharmonic signals and pressure catheter data ranged from -0.3 to -0.9. For acquisitions with optimum acoustic output, pressure errors between the subharmonic technique and catheter were as low as 2.6 mmHg. However, automatically determining optimum acoustic output during scanning for each patient remains to be addressed before clinical applicability can be decided.

• 出版日期2017-11