A method for estimating intracellular sodium concentration and extracellular volume fraction in brain in vivo using sodium magnetic resonance imaging

作者：Madelin Guillaume^*; Kline Richard; Walvick Ronn; Regatte Ravinder R

来源：Scientific Reports, 2014, 4(1): 4763.

DOI：10.1038/srep04763

In this feasibility study we propose a method based on sodium magnetic resonance imaging (MRI) for estimating simultaneously the intracellular sodium concentration (C-1, in mM) and the extracellular volume fraction (alpha) in grey and white matters (GM, WM) in brain in vivo. Mean C-1 over five healthy volunteers was measured similar to 11 mMin both GM and WM, mean alpha was measured similar to 0.22 in GM and similar to 0.18 in WM, which are in close agreement with standard values for healthy brain tissue (C-1 similar to 10-15 mM, alpha similar to 0.2). Simulation of 'fluid' and 'solid' inclusions were accurately detected on both the C-1 and alpha 3D maps and in the C-1 and alpha distributions over whole GM and WM. This non-invasive and quantitative method could provide new biochemical information for assessing ion homeostasis and cell integrity in brain and help the diagnosis of early signs of neuropathologies such as multiple sclerosis, Alzheimer's disease, brain tumors or stroke.

• 出版日期2014-4-23