科研之友
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摘要
Traumatic brain injury is a problem that affects millions of Americans yearly and for which there is no definitive treatment that improves outcome. Continuous brain tissue oxygen (P-btO2) monitoring is a complement to traditional brain monitoring techniques, such as intracranial pressure and cerebral perfusion pressure. P-btO2 monitoring has not yet become a clinical standard of care, due to several unresolved questions. In this review, we discuss the rationale and technology of P-btO2 monitoring. We review the literature, both historic and current, and show that continuous P-btO2 monitoring is feasible and useful in patient management. P-btO2 numbers reflect cerebral blood flow and oxygen diffusion. Thus, continuous monitoring of P-btO2 yields important information about both the brain and the lung. The preclinical and clinical studies demonstrating these findings are discussed. In this review, we demonstrate that patient management in a P-btO2 - directed fashion is not the sole answer to the problem of treating traumatic brain injury but is an important adjunct to the armamentarium of multimodal neuromonitoring.
- 出版日期2016-9
