An efficient and general route to the synthesis of diethyl alpha,alpha-bromofluorophosphonates

作者：Fu, Jian Ping; He, Yan Hong; Zhong, Jun; Yang, Yang; Deng, Xiang; Guan, Zhi^*

来源：Journal of Fluorine Chemistry, 2011, 132(9): 636-640.

DOI：10.1016/j.jfluchem.2011.06.016

• Bromination
• Fluorination
• Diethyl alpha-bromophosphonate
• Diethyl alpha,alpha-bromofluorophosphonate

An efficient and general two-step halogenation procedure to prepare diethyl alpha,alpha-bromofluorophosphonates was described, which included bromination by PPh3, 2,3-dichloro-5,6-dicyanobenzquinone (DDQ) and n-Bu4NBr, and electrophilic fluorination by N-fluorobisbenzenesulfonimide (NFSI). Both aromatic and aliphatic alpha,alpha-bromofluorophosphonates could be prepared by this method.

• 出版日期2011-9
• 单位西南大学