Uric Acid and Gamma-glutamyl Transferase Activity Are Associated With Left Ventricular Remodeling Indices in Patients With Chronic Heart Failure

作者：Radovanovic Slavica; Savic Radojevic Ana; Pekmezovic Tatjana; Markovic Olivera; Memon Lidija; Jelic Svetlana; Simic Dragan; Radic Tanja; Pljesa Ercegovac Marija; Simic Tatjana^*

来源：Revista Espanola de Cardiologia, 2014, 67(8): 632-642.

DOI：10.1016/j.rec.2013.11.017

• Gamma-glutamyl transferase
• Uric acid
• Chronic heart failure
• Remodeling
• Flow mediated dilation
• Oxidative stress

Introduction and objectives: Uric acid and gamma-glutamyl transferase are prognostic indicators in chronic heart failure. Nevertheless, the mechanism underlying the association between uric acid, gamma-glutamyl transferase, and chronic heart failure progression and prognosis remains largely unknown.
Methods: The association of uric acid and gamma-glutamyl transferase with flow-mediated dilation and echocardiographic indices of cardiac remodeling was addressed in 120 patients with chronic ischemic heart failure. To determine the independent contribution of uric acid and gamma-glutamyl transferase to the flow-mediated dilation and echocardiographic indices of remodeling, a series of multiple linear regression models, based on traditional and nontraditional risk factors impacting upon these parameters, were constructed.
Results: Uric acid, but not gamma-glutamyl transferase, was an independent predictor of flow-mediated dilation. Uric acid was associated with all the echocardiographic indices of left ventricular dysfunction tested in 3 multiple-regression models. Uric acid correlated with left ventricular end-systolic diameter, left ventricular end-diastolic diameter, left ventricular end-systolic volume, and left ventricular enddiastolic volume (r = 0.337; r = 0.340; r = 0.321; r = 0.294; P =.001, respectively). Gamma-glutamyl transferase was an independent predictor of left ventricular end-systolic volume and left ventricular enddiastolic volume, after adjustment for all variables. Gamma-glutamyl transferase correlated with left ventricular end-systolic diameter, left ventricular end-diastolic diameter, left ventricular end-systolic volume, and left ventricular end-diastolic volume (r = 0.238, P = .009; r = 0.219, P = .016; r = 0.359, P < .001; r = 0.369, P =.001, respectively).
Conclusions: Serum uric acid and gamma-glutamyl transferase levels are associated with left ventricular remodeling in patients with chronic ischemic heart failure.

• 出版日期2014-8
• 单位河北医科大学