Dermal CD271(+) Cells are Closely Associated with Regeneration of the Dermis in the Wound Healing Process

作者：Iwata Yohei^*; Hasebe Yuichi; Hasegawa Seiji; Nakata Satoru; Yagami Akiko; Matsunaga Kayoko; Sugiura Kazumitsu; Akamatsu Hirohiko

来源：Acta Dermato-Venereologica, 2017, 97(5): 593-600.

DOI：10.2340/00015555-2624

• CD271
• p75NTR
• stem cell
• wound healing
• collagen type V

Stem cells have recently been shown to play important roles in wound healing. The aim of this study was to investigate the role of dermal CD271(+) cells in wound healing. Full-thickness wounds were produced on the backs of 5-year-old and 24-week-old mice, and time course of wound closure, CD271(+) cell counts, and gene expression levels were compared. Delayed wound healing was observed in 24-week-old mice. The peak of CD271(+) cell increase was delayed in 24-week-old mice, and gene expression levels of growth factors in wounded tissue were significantly increased in 5-year-old mice. Dermal CD271(+) cells purified by fluorescence-activated cell sorting (FACS) expressed higher growth factors than CD271(-) cells, suggesting that CD271(+) cells play important roles by producing growth factors. This study also investigated dermal CD271(+) cells in patients with chronic skin ulcers. Dermal CD271(+) cells in patients were significantly reduced compared with in healthy controls. Thus, dermal CD271(+) cells are closely associated with wound healing.

• 出版日期2017-5