A new phenanthroline-oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction

作者：McCann Malachy^*; McGinley John; Ni Kaijie; O' Connor Mark; Kavanagh Kevin; Mckee Vickie; Colleran John; Devereux Michael; Gathergood Nicholas; Barron Niall; Prisecaru Andreea; Kellett Andrew

来源：Chemical Communications, 2013, 49(23): 2341-2343.

DOI：10.1039/c3cc38710k

1,10-Phenanthroline-5,6-dione and L-tyrosine methyl ester react to form phenanthroline-oxazine (PDT) from which [Cu(PDT)(2)](ClO4)(2) and [Ag(PDT)(2)]ClO4 center dot 2MeOH are obtained. Binding to calf-thymus DNA by Ag(I) and Cu(II) PDT complexes exceed bis-1,10-phenanthroline analogues and the minor groove binding drugs, pentamidine and netropsin. Furthermore, unlike the artificial metallonuclease, [Cu(phen)(2)](2+), the [Cu(PDT)(2)](2+) complex does not cleave DNA in the presence of added reductant indicating unique interaction with DNA.

• 出版日期2013