Mitochondrial helicases and mitochondrial genome maintenance

作者：de Souza Pinto Nadja C^*; Aamann Maria D; Kulikowicz Tomasz; Stevnsner Tinna V; Bohr Vilhelm A

来源：Mechanisms of Ageing and Development, 2010, 131(7-8): 503-510.

DOI：10.1016/j.mad.2010.04.009

• Mitochondrial DNA
• Helicases
• BER
• Aging
• mtDNA deletions

Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus.

• 出版日期2010-8