Muscle strength and executive function as complementary parameters for the assessment of impairment in Parkinson%26apos;s disease

作者：Barbirato Dannyel; Carvalho Alessandro; de Araujo Narahyana Bom; Martins Jose Vicente; Deslandes Andrea^*

来源：Arquivos de Neuro-Psiquiatria, 2013, 71(12): 948-954.

DOI：10.1590/0004-282X20130175

• Parkinson%26apos
• s disease
• cognitive function
• functional capacity
• executive function
• disease severity

Objective: To evaluate the relationship between the quantitative results of functional and cognitive performance of patients with Parkinson%26apos;s disease (PD) and disease severity; and to study the relationship between patients%26apos; functional and cognitive capacity and motor impairment (Unified Parkinson%26apos;s Disease Rating Scale-UPDRS III). Method: Twenty-nine subjects clinically diagnosed with PD were classified into three groups according to disease severity using the modified Hoehn and Yahr Scale (H%26Y). They were submitted to functional (Senior Fitness Test) and neuropsychological tests. Stepwise regression analysis showed a significant association between H%26Y and upper limb strength (r(2)= 0.30; p=0.005) and executive r(2)=0.37; p=0.004). In relation to UPDRS III, there was a significant association between lower limb strength (r(2)=0.27; p=0.010) and global cognitive status (r(2)=0.24; p=0.024). Conclusion: The implementation of simple tests of functional capacity associated with neuropsychological testing can help to assess disease severity and motor impairment, and can be used to monitor the response to treatment in PD.

• 出版日期2013-12