Association between serum 25-hydroxyvitamin D levels and pulmonary function, among Korean adults, during 2010-2014, by sex, age, and body mass index

作者：Shim Sun Young; Chae Won Jeong; Kim Hyeon Chang; Park Eun Cheol; Jang Sung In^*

来源：Respiratory Medicine, 2018, 140: 32-38.

DOI：10.1016/j.rmed.2018.05.011

• Serum 25-hydroxyvitamin D
• Pulmonary function
• Epidemiology

Background: This study examined the association between serum 25-hydroxyvitamin D (25(OH) D) and pulmonary function, among Korean adults, from 2010 to 2014.
Methods: The data were obtained from the fifth Korea National Health and Nutrition Examination Survey (KNHANES 5), and the first and second year (2013-2014) of KNHANES 6. The study population comprised 14,378 individuals. The variable of interest was serum 25(OH) D, and the dependent variable, pulmonary function.
Results: All people with vitamin D levels below 30 ng/ml had lower lung functions, which was significant in lower forced expiratory volume in the first second (FEV1) (serum 25(OH) D < 10 ng/ml, 20 to < 30 ng/ml: P=.001, 10 to < 20 ng/ml: P=0) and forced vital capacity (FVC) (serum 25(OH) D level < 10 ng/ml: P=.01, 10 to < 20 ng/ml: P=.001, 20 to < 30 ng/ml: P=.008). The lower the serum 25(OH) D, the lower the levels of FEV1 in men and this was significant. (serum 25(OH) D < 10 ng/ml: P=.007, 10 to < 20 ng/ml: P=.002, 20 to < 30 ng/ml: P=.007). The values of FEV1 and FVC were lower in people aged 50-69 years when vitamin D was lower than 30 ng/ml which were all significant. Among participants with BMI values < 23 kg/m(2), lower vitamin D levels were significantly associated with lower pulmonary function.
Conclusions: We found a significant association between serum 25(OH) D and pulmonary function, and this was related to sex, age and body mass index.

• 出版日期2018-7