DESIGN AND SYNTHESIS OF RAPIDLY PHOTO-CROSSLINKABLE BIOACTIVE BIODEGRADABLE HYDROGELS

作者：Deng, Chao^*; Wang, Rong; Chen, Wei; Meng, Feng-hua; Cheng, Ru; Zhong, Zhi-yuan

来源：Acta Polymerica Sinica, 2013, 013(5): 695-704.

DOI：10.3724/SP.J.1105.2013.12426

• Hydrogel
• Photo-crosslinking
• Biodegradable
• Bioactive
• RGD peptide
• Tissue engineering

A series of water-soluble biodegradable oligo (lactide-co-acryloyl carbonate)-b-poly(ethylene glycol)-b-oligo(lactide-co-acryloyl carbonate) (OLAC-PEG-OLAC) triblock copolymers were synthesized by ring-opening copolymerization of lactide (LA) and acryloyl cyclic carbonate (AC) and applied for in situ formation of novel bioactive biodegradable hydrogels via photo-crosslinking. The rheology measurements showed that gelation times (0. 8 similar to 8 min) and storage moduli (170 similar to 10000 Pa) of hydrogels could be controlled by AC content,polymer concentration and photo-initiator concentration. The results of degradation tests displayed that degradation rates of these hydrogels could be tailored by AC and LA contents. Notably, the multiple acryloyl functional groups in OLAC-PEG-OLAC copolymers allowed direct conjugation of thiol-containing biomolecules like RGD peptides via Michael addition reaction prior to gelation, which provides a facile access to injectable bioactive biodegradable hydrogels. The preliminary cell experiments demonstrated that RGD peptide modified hydrogels could well support adhesion and growth of MG63 osteoblast cells. These rapidly photo-crosslinkable biodegradable hydrogels with controlled mechanical properties, tailored biodegradation rates, and versatile bio-functionalization form an excellent basis for the development of advanced bioactive tissue engineering scaffolds.

• 出版日期2013-5-20
• 单位苏州大学