Selective Imaging of Quorum Sensing Receptors in Bacteria Using Fluorescent Au Nanocluster Probes Surface Functionalized with Signal Molecules

作者：Mukherji Ruchira; Samanta Anupam; Illathvalappil Rajith; Chowdhury Somak; Prabhune Asmita^*; Devi R Nandini

来源：ACS Applied Materials & Interfaces, 2013, 5(24): 13076-13081.

DOI：10.1021/am404093m

• quorum sensing
• Au nanoclusters
• fluorescence imaging
• biosensor

Fluorescent ultrasmall gold clusters decorated with bacterial quorum sensing signal molecules, acyl homoserine lactone, are synthesized. These fluorescent probes are found to have emission in the near-infrared spectral region advantageous for bioimaging. Imaging studies using different. strains of bacteria with and without acyl homoserine lactone receptors with the aid of confocal microscopy have shown that the probe interacts preferentially with cells possessing these receptors. This indicates that, with appropriate surface functionalization, the Au clusters can be used for receptor specific detection with enhanced selectivity.

• 出版日期2013-12-25