NMR spectroscopy of G-quadruplexes

作者：Adrian Michael; Heddi Brahim; Anh Tuan Phan^*

来源：Methods, 2012, 57(1): 11-24.

DOI：10.1016/j.ymeth.2012.05.003

• DNA
• G-quadruplex
• NMR
• RNA

G-rich DNA and RNA sequences can form four-stranded structures called G-quadruplexes. Such structures have gained significant interest in the past decade with increasing evidence of their biological role. G-quadruplex structures can be polymorphic and dynamic. NMR spectroscopy has played an important role in G-quadruplex research. Here we review on the application of NMR techniques to study structure, dynamics and interaction of G-quadruplexes.

• 出版日期2012-5
• 单位南阳理工学院