NONRANDOM ASSOCIATION BETWEEN DNA MARKERS AND HUNTINGTON DISEASE LOCUS IN THE ITALIAN POPULATION

作者：NOVELLETTO A^*; MANDICH P; BELLONE E; MALASPINA P; VIVONA G; AJMAR F; FRONTALI M

来源：American Journal of Medical Genetics, 1991, 40(3): 374-376.

DOI：10.1002/ajmg.1320400326

• LINKAGE DISEQUILIBRIUM
• CHROMOSOME 4P MARKERS

A group of Huntington disease (HD) families of Italian ancestry was analyzed for 11 RFLPs from genetic loci mapped in 4p16 and genetically linked to the HD gene. We found a statistically significant difference of allele distributions in HD vs normal chromosomes for loci D4S10, D4S127, and D4S43. This observation increases the number of loci in linkage disequilibrium with HD. However, the amount of disequilibrium does not allow either a finer localization of the HD gene or a substantial improvement in risk calculations.

• 出版日期1991-9-1