Anti-N-Methyl-D-Aspartate Receptor Encephalitis and Its Anesthetic Implications

作者：Pryzbylkowski Peter Gabriel; Dunkman William Jonathan; Liu Renyu; Chen Linda^*

来源：Anesthesia and Analgesia, 2011, 113(5): 1188-1191.

DOI：10.1213/ANE.0b013e31822b8a7d

We describe the anesthetic management and implications of 2 patients with anti-N-methyld-aspartate (NMDA) receptor encephalitis. Anti-NMDA receptor encephalitis is a neurological disorder caused by production of antibodies to the NMDA receptor. The NMDA receptor is the target of many drugs used in anesthesia. It is important to understand the pharmacologic interactions these anesthetics have with a disabled NMDA receptor while preparing an anesthetic plan for patients with anti-NMDA receptor encephalitis. Symptoms of the disease such as psychosis, paroxysmal sympathetic hyperactivity, and central hypoventilation pose risks to the induction and maintenance of anesthesia in these patients. (Anesth Analg 2011; 113: 1188-91)

• 出版日期2011-11