Anti-liver fibrotic lignans from the fruits of Schisandra arisanensis and Schisandra sphenanthera

作者：Chen Yu Chen; Liaw Chia Ching; Cheng Yuan Bin; Lin Yu Chi; Chen Chung Hsiung; Huang Yi Tasu; Liou Shorong Shii; Chen Shun Ying; Chien Ching Te; Lee Guo Chi; Shen Ya Ching^*

来源：Bioorganic & Medicinal Chemistry Letters, 2013, 23(3): 880-885.

DOI：10.1016/j.bmcl.2012.11.040

• Schisandra
• C-18-dibenzocyclooctadiene lignans
• Anti-hepatic fibrosis

Three new polyoxygenated C-18-dibenzocyclooctadiene lignans, arisanschinins M and N (1 and 2) and schisphenin A (3), together with eight related metabolites (4-11), were isolated from the fruits of Schisandra arisanensis and Schisandra sphenanthera, respectively. The structures of 1-3 were elucidated on the basis of extensive spectroscopic and 2D NMR (HSQC, HMBC, and NOESY) analyses. The configuration of the biphenyl moiety in the octadiene ring was determined by circular dichroism (CD). Compound 1 possessed an unprecedented 3-(1-hydroxypropan-2-yl)-3-methyl-1,4-dioxo-2-one lactonide ring system attaching at C-6/C-14. Pharmacological studies revealed that compounds 3, 4, 6, 7, and 10 exhibited significant anti-hepatic fibrosis activity, while 9 and 11 showed cytotoxicity against HSC-T6 cells. The bio-genetic pathway for compound 1 was also proposed.

• 出版日期2013-2-1