Toll Like Receptor 4 D299G Associates with Disease Progression in Caucasian Patients with Chronic HBV Infection: Relationship with Gender

作者：Cussigh Annarosa; Fabris Carlo; Fattovich Giovanna; Falleti Edmondo; Cmet Sara; Bitetto Davide; Bignulin Eleonora; Toniutto Pierluigi^*

来源：Journal of Clinical Immunology, 2013, 33(2): 313-316.

DOI：10.1007/s10875-012-9822-9

• Toll like receptor 4
• genetic polymorphism
• gender
• hepatitis B virus
• cirrhosis

This study aimed to verify whether rs4986790 A %26gt;G single nucleotide polymorphism of toll like receptor 4 (TLR-4) associates with a more severe course of hepatitis B virus (HBV) chronic infection. A cross-sectional study enrolled 191 Caucasian HBV-positive patients: 28 HBsAg+inactive carriers, 121 chronic hepatitis B, 42 HBsAg+transplant candidates. A longitudinal study included 94 patients followed-up for a median time of 19.3 years. TLR-4 rs4986790 A/A genotype was carried less frequently in male HBsAg+inactive carriers than in males with HBsAg+active chronic infection (12/17 Vs 109/121, p=0.022). At stepwise logistic regression analysis, the carriage of TLR-4 rs4986790 A/A genotype was found to be and independent predictor of liver fibrosis (O.R. 14.8, p=0.019). In conclusion, in HBV-positive Caucasian patients, the A/A genotype of the rs4986790 polymorphism may influence a worse outcome of chronic HBV infection, mainly through a synergistic interaction with male gender.

• 出版日期2013-2