A New Method for the Preparation of Gelatin Nanoparticles: Encapsulation and Drug Release Characteristics

作者：Naidu B Vijaya Kumar; Paulson Allan T^*

来源：Journal of Applied Polymer Science, 2011, 121(6): 3495-3500.

DOI：10.1002/app.34171

• gelatin
• nanoparticles
• encapsulation
• 5-fluorouracil

A new and simple method was developed to produce gelatin nanoparticles of similar to 30-40 nm for use as carriers for drug release applications. The nanoparticles were uniform in size and well dispersed. An anticancer drug, 5-fluorouracil, was encapsulated with an efficiency as high as 85%. The nanoparticles showed sustained release of 5-fluorouracil, and release rates varied with amount of crosslinking in the nanoparticles.

• 出版日期2011-9-15