Amino acid based enantiomerically pure 3-substituted benzofused heterocycles: A new class of antithrombotic agents

作者：Mishra Jitendra Kumar; Samanta Krishnananda; Jain Manish; Dikshit Madhu^*; Panda Gautam

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(1): 244-247.

DOI：10.1016/j.bmcl.2009.10.126

• Amino acids
• Benzodiazepines
• Benzoxazepines
• Benzothiazepines
• Benzoxazocine
• Antithrombotic activity

A diverse group of novel medium ring heterocycles derived from naturally abundant proteinogenic amino acids were evaluated for their potency towards antithrombotic activity. The more potent benzofused oxazepine and oxazocine scaffolds were diversified by incorporating different amino acids at the position number 3. Further the effect of ring size has also been taken into account and it was observed that the eight-membered oxazocines ane more potent compared to the corresponding oxazepines.

• 出版日期2010-1-1