An optimal control problem in cancer chemotherapy

作者:Krabs Werner; Pickl Stefan*
来源:Applied Mathematics and Computation, 2010, 217(3): 1117-1124.
DOI:10.1016/j.amc.2010.05.008

摘要

We consider a mathematical model for the control of the growth of tumor cells which is formulated as a problem of optimal control theory. It is concerned with chemotherapeutic treatment of cancer and aims at the minimization of the size of the tumor at the end of a certain time interval of treatment with a limited amount of drugs. The treatment is controlled by the dosis of drugs that is administered per time unit for which also a limit is prescribed. It is shown that optimal controls are of bang-bang type and can be chosen at the upper limit, if the total amount of drugs is large enough.

  • 出版日期2010-10-1