Long-term overall and disease-specific mortality associated with benign gynecologic surgery performed at different ages

作者：Gierach Gretchen L^*; Pfeiffer Ruth M; Patel Deesha A; Black Amanda; Schairer Catherine; Gill Abegail; Brinton Louise A; Sherman Mark E

来源：Menopause-The Journal of the North American Menopause Society, 2014, 21(6): 592-601.

DOI：10.1097/gme.0000000000000118

• Bilateral oophorectomy
• Cohort studies
• Hysterectomy
• Mortality

Objective: As bilateral salpingo-oophorectomy is frequently performed with hysterectomy for nonmalignant conditions, defining health outcomes associated with benign bilateral salpingo-oophorectomy performed at different ages is critical.
Methods: We assessed mortality risk associated with benign total abdominal hysterectomy or bilateral salpingo-oophorectomy among 52,846 Breast Cancer Detection Demonstration Project follow-up study participants. Surgery and risk factor data were ascertained via baseline interview (1979-1986) and three questionnaires (1987-1998). During follow-up through December 2005 (mean, 22.1 y), 13,734 deaths were identified. We estimated hazard ratios (HRs) and 95% CIs for overall and disease-specific mortality for total abdominal hysterectomy or bilateral salpingo-oophorectomy performed by age 35, 40, 45, 50, or 55 years, compared with not having surgery, using landmark analyses and multivariable Cox regression.
Results: Undergoing bilateral salpingo-oophorectomy by age 35 years was associated with increased mortality risk (HR35 (y), 1.20; 95% CI, 1.08-1.34), which decreased with age (HR40 (y), 1.12; 95% CI, 1.04-1.21; HR45 (y), 1.10; 95% CI, 1.03-1.17). Total abdominal hysterectomy alone performed by age 40 years was associated with increased mortality risk to a lesser extent (HR40 y, 1.08; 95% CI, 1.01-1.15). Analyses based on matched propensity scores related to having gynecologic surgery yielded similar results. Elevated mortality risks were largely attributable to noncancer causes.
Conclusions: Benign gynecologic surgeries among young women are associated with increased mortality risk, which attenuates with age.

• 出版日期2014-6