ANTICHOLINESTERASE ACTIVITY AND CHEMICAL PROFILE OF AN ACTIVE CHROMATOGRAPHIC FRACTION OF ETHANOLIC EXTRACT FROM Bellis perennis L. (Asteraceae) FLOWERS

作者：Costa Marques Thiago Henrique; dos Santos Pauline Sousa; de Freitas Rivelilson Mendes; Fonseca de Carvalho Ru**ene Bruno; Santos de Melo Cassio Herbert; David Juceni Pereira; David Jorge Mauricio; Lima Luciano Silva

来源：Quimica Nova, 2013, 36(4): 549-U241.

• anticholinesterase activity
• B. perennis
• isorhamnetin 3-O-beta-D-(6''-acetyl)-galactopyranoside

This work describes the isolation of an active flavonoid fraction and identification of isorhamnetin 3-O-beta-D-(6''-acetyl)-galactopyranoside from flowers of B. perennis, and also the evaluation of anticholinesterase (AChE) activity of ethanolic extract from flowers (EEF) and the active fraction. The chemical structure of the flavonoid was defined on the basis of spectroscopic H-1 NMR, IR and UV data. EEF or flavonoid reduces AChE activity in vivo, while flavonoid also reduces AChE activity in vitro, showing a value of 1.49 mu M for 50% inhibitory concentration (IC50), suggesting potential use as an insecticide or in the treatment of neurodegenerative diseases such as Alzheimer's disease.

• 出版日期2013