Application of Ynamides in the Synthesis of 2-Amidoindoles

作者:Dooleweerdt Karin; Ruhland Thomas*; Skrydstrup Troels
来源:Organic Letters, 2009, 11(1): 221-224.
DOI:10.1021/ol802477d

摘要

A Pd-catalyzed, one-pot, two-step synthesis of 2-amidoindoles from ynamides and o-lodoanilines Is reported. A key highlight of this sequence is that after the Sonogashira reaction, intramolecular cyclization to the indole occurs spontaneously without activation of the alkyne.

  • 出版日期2009-1-1