NO MUTATION OF THE CATALASE GENE IN CANCER-PATIENTS

作者：KISHIMOTO Y^*; MURAKAMI Y; HAYASHI K; TAKAHARA S; SUGIMURA T; SEKIYA T

来源：Proceedings of the Japan Academy Series B-Physical and Biological Sciences, 1991, 67(2): 7-10.

DOI：10.2183/pjab.67.7

• CATALASE GENE
• LUNG CANCER
• HEPATOCELLULAR CARCINOMA
• SINGLE-STRAND CONFORMATION POLYMORPHISM ANALYSIS

The involvement of active oxygens in the genesis of human cancers has been proposed, and reduced catalase activity in cancer cells has been reported. To elucidate the possible involvement of aberrations of the catalase gene in carcinogenesis, we examined DNAs from tissues of cancer patients by single-strand conformation polymorphism analysis of polymerase chain reaction products. No mutation of the catalase gene was observed in 20 lung cancers analyzed or in noncancerous portions of the liver of 11 patients with hepatocellular carcinoma. These findings suggest that the catalase gene is not involved significantly, if at all, in tumorigenesis.

• 出版日期1991-2