Secondary Diffuse Large B-cell Lymphoma After Chemotherapy for Acute Myeloid Leukemia: Looking for the Unexpected Diagnosis

作者：Ririe Marnie R^*; Florell Scott R; Miles Rodney R; Duffy Keith L

来源：American Journal of Dermatopathology, 2014, 36(7): E125-E128.

• diffuse large B-cell lymphoma
• acute myeloid leukemia
• immunohistochemical
• Epstein-Barr virus
• immunosuppression

Development of Epstein-Barr virus (EBV) positive lymphoproliferative disorders in patients with immunosuppression has become more frequently reported. A patient with acute myeloid leukemia was treated to remission, when on follow-up 9 months after his initial diagnosis, he was noted to have a generalized rash and lymphadenopathy. Evaluation of skin and bone marrow biopsies was suggestive of a relapsed leukemia, and treatment was initiated. Fever evaluation revealed a high load of EBV in his blood. A lymph node biopsy and retrospective examination of his skin and bone marrow revealed an EBV-positive diffuse large B-cell lymphoma with no recurrence of acute myeloid leukemia. His chemotherapy-induced immunosuppression likely predisposed him to develop this EBV-positive diffuse large B-cell lymphoma. This case highlights the need to consider a broader differential and immunohistochemical profiling of these neoplasms to avoid misdiagnosing complex oncology patients.

• 出版日期2014-7