Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides

作者：Wang, Sheng; Xie, Wenxian; Zhang, Xiu; Zou, Xia; Zhang, Yan^*

来源：Chemical communications, 2012, 48(47): 5907-5909.

DOI：10.1039/c2cc18160f

• NEWLY SYNTHESIZED PROTEINS
• GLCNAC-MODIFIED PROTEINS
• CHEMICAL REPORTERS
• IDENTIFICATION
• CYCLOADDITION
• PEPTIDES
• GLYCOSYLATION
• PROBES
• CELLS

Disulfide- and terminal alkyne-modified magnetic silica particles (DA-MSPs) were synthesized and used to covalently capture and reductively release azido glycopeptides via click chemistry and dithiothreitol treatment. Using DA-MSPs, an efficient and specific enrichment method for separating azido glycopeptides has been developed.

• 出版日期2012
• 单位上海交通大学