Association of Lower Plasma Fetuin-A Levels With Peripheral Arterial Disease in Type 2 Diabetes

作者：Epaso Luis H; Ginwala Naeema; Qasim Atif N; Mehta Nehal N; Dlugash Rachel; Kapoor Shiv; Schwartz Stanley; Schutta Mark; Iqbal Nayyar; Mohler Emile R III; Reilly Muredach P^*

来源：Diabetes Care, 2010, 33(2): 408-410.

DOI：10.2337/dc09-1541

OBJECTIVE - Fetuin-A is an inhibitor of Vascular calcification and a mediator of insulin resistance. This study evaluated the association of plasma fetuin-A and peripheral arterial disease (PAD).
RESEARCH DESIGN AND METHODS - A total of 738 individuals with type 2 diabetes(mean age 58.7 years, 37.1% female)without known cardiovascular or kidney disease were included in this cross-sectional analysis.
RESULTS - Subjects with PAD had a significantly lower fetuin-A (264.3 vs. 293.4 ng/dl, P < 0.001). In multivariable analysis, a 1-SD decrease in fetuin-A increased the odds of PAD (odds ratio 1.6, P = 0.02). Subgroup analysis revealed an increased odds even in subjects With glomerular filtration rate >80 (odds ratio 1.9, P = 0.05) or high-sensitivity C-reactive protein <3 mg/dl (odds ratio 2.7, P = 0.002).
CONCLUSIONS - Lower circulating Fetuin-A is associated with PAD in type 2 diabetes beyond traditional and novel cardiovascular risk factors. Our findings suggest a potentially unique role for fetuin-A deficiency as a biomarker of PAD in patients with type 2 diabetes.

• 出版日期2010-2