A novel method of ultrasound-assisted dispersive liquid-liquid microextraction coupled to liquid chromatography-mass spectrometry for the determination of trace organoarsenic compounds in edible oil

作者：Wang, Wei-Xun; Yang, Tzung-Jie; Li, Zu-Guang; Jong, Ting-Ting; Lee, Maw-Rong^*

来源：Analytica Chimica Acta, 2011, 690(2): 221-227.

DOI：10.1016/j.aca.2011.02.033

• Ultrasound-assisted dispersive liquid-liquid microextraction
• Organoarsenicals
• Edible oil
• Liquid chromatography-mass spectrometry

A novel approach, ultrasound-assisted dispersive liquid-liquid microextraction combined with liquid chromatography-mass spectrometry (UA-DLLME with LC-MS) is demonstrated to be quite useful for the determination of trace amounts of organoarsenic compounds in edible oil. The organoarsenic compounds studied include dimethylarsinic acid (DMA), monomethylarsonic acid (MMA) and 3-nitro-4-hydroxyphenyl arsenic acid (Roxarsone). Orthogonal array experimental design (OAD) was utilized to investigate the parameter space of conditions for UA-DLLME. The optimum conditions were found to be 4 min of ultrasonic extraction using 1.25 mL of mixed solvent with 50 mu L of buffer solution. Under these optimal conditions, the linear range was from 10 ng g(-1) tc 500 ng g(-1) for DMA and Roxarsone, from 25 ng g(-1) to 500 ng g(-1) for MMA. Limits of detection of DMA, MMA and Roxarsone were 1.0 ng g(-1), 3.0 ng g(-1) and 5.8 ng g(-1), respectively. The precisions and recoveries also were investigated by spiking 3-level concentrations in edible oil. The recoveries obtained were over 89.9% with relative standard deviation (RSD) of 9.6%. The new approach was utilized to successfully detect trace amounts of organoarsenic compounds in various edible oil samples.

• 出版日期2011-4-1
• 单位浙江工业大学