Decoding the RNA structurome

作者：Lu Zhipeng; Chang Howard Y

来源：Current Opinion in Structural Biology, 2016, 36: 142-148.

DOI：10.1016/j.sbi.2016.01.007

Structures of RNA molecules are essential for their architectural, regulatory, and catalytic functions. Recent advances in high throughput sequencing enabled the development of methods for, probing RNA structures on a transcriptome-wide scale termed the RNA structurome. Here we review the state-of-the-art technologies for probing the RNA structurome, and highlight insights gained from these studies. We also point out the limits of current methods and discuss potential directions for future improvements.

• 出版日期2016-2