An investigation of a possible relationship between olfactory identification deficits at first episode and four-year outcomes in patients with psychosis

作者：Good Kimberley P^*; Tibbo Philip; Milliken Heather; Whitehorn David; Alexiadis Maria; Robertson Nancy; Kopala Lili C

来源：Schizophrenia Research, 2010, 124(1-3): 60-65.

DOI：10.1016/j.schres.2010.07.010

• Olfaction
• First episode psychosis
• Functional outcome

Objective Olfactory identification deficits are found in a significant proportion of patients with schizophrenia spectrum psychotic disorders and appear to be predictive of incomplete remission of negative and cognitive symptoms In the current study we examined whether patients with first episode psychosis who have olfactory identification deficits (microsmic) have poorer functional outcome than those whose olfactory status is normal (normosmic)
Method Sixty-six (66) first episode psychosis patients (46 M and 20 F) were assessed with the University of Pennsylvania Smell Identification Test (UPSIT) at baseline UPSIT scores served to classify patients into subgroups The patients psychiatrists completed the Social and Occupational Functioning Assessment Scale (SOFAS) and the Levels of Functioning Scale (LOFS) after at least 6 months of treatment The Premorbid Assessment Scale (PAS) was rated by a parent at baseline
Results Thirty-eight percent (38%) of the sample was identified as microsmic LOFS and SOFAS scores were significantly lower in the microsmic group than in the normosmic group Symptoms were significantly worse in the microsmic group in comparison to the normosmic group PAS scores did not differ between groups
Conclusions First episode patients identified as microsmic at baseline assessment went on to demonstrate poorer functional outcome compared to normosmic patients despite no differences in premorbid adjustment Olfactory identification deficits at first episode may provide a marker for poorer outcome Testing olfaction is simple and inexpensive and could provid

• 出版日期2010-12