Aspirin Intake Correlates With Halted Growth of Sporadic Vestibular Schwannoma In Vivo

作者：Kandathil Cherian K; Dilwali Sonam; Wu Chen Chi; Ibrahimov Metin; McKenna Michael J; Lee Hang; Stankovic Konstantina M^*

来源：Otology & Neurotology, 2014, 35(2): 353-357.

DOI：10.1097/mao.0000000000000189

• Aspirin intake
• Decreased tumor growth
• In vivo
• Retrospective case review
• Sporadic vestibular schwannoma

Objective: Given the presence of a pathological immune response in sporadic vestibular schwannoma (sVS), this study aims to explore the roles of aspirin in minimizing sVS growth in vivo.
Study Design: Retrospective case review.
Setting: Tertiary care hospital.
Patients: People diagnosed with sVS and followed at a tertiary referral center by serial magnetic resonance imaging (MRI) for at least 4 months within the period of January 1980 through April 2012.
Main Outcome Measures: Patient use of aspirin and sVS growth rate measured by changes in the largest tumor dimension as noted on serial MRIs
Results: Within a set of 689 cases, 347 were followed by serial MRI scans (50.3%); of the latter, 81 took aspirin, of which, 33 demonstrated sVS growth, and 48 did not. Of the 266 nonaspirin users, 154 demonstrated sVS growth, and 112 did not. A significant inverse association was found among aspirin users and sVS growth (odds ratio [OR]: 0.50, 95% confidence interval [CI]: 0.29-0.85), which was not confounded by age or sex.
Conclusion: Our results suggest a potential therapeutic role of aspirin in inhibiting sVS growth.

• 出版日期2014-2
• 单位MIT