Marginal zone lymphoma of mucosa-associated lymphoid tissue with prominent plasma cell differentiation affecting the palatine tonsil: histopathological and immunohistochemical analysis

作者：Carlos Bregni Roman; Nuyens Michel; Vassallo Jose; Soares Fernando Augusto; Romanach Mario Jose; Leon Jorge Esquiche^*; Almeida Oslei Paes

来源：Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 2012, 113(4): 526-532.

DOI：10.1016/j.oooo.2011.11.002

Non-Hodgkin lymphomas (NHLs) of the oral cavity and oropharynx constitute 13% of all primary extranodal NHLs. Marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) in the palatine tonsil is rare, corresponding to 6% of the NHLs of the Waldeyer ring. Some cases of MALT lymphoma can present prominent plasma cell differentiation, and less commonly, monoclonal gammopathy. The differential diagnosis of these cases from other NHLs with plasmacytic differentiation or plasma cell neoplasms is very difficult. In this article, we describe a rare case of MALT lymphoma in a 34-year-old man presenting as a swelling of the palatine tonsil. The tumor mass was diagnosed as MALT lymphoma with prominent plasma cell differentiation. Systemic evaluation was noncontributory. This is the first report of MALT lymphoma showing extensive plasmacytic differentiation of the palatine tonsil, and reinforces a possible relationship between extramedullary plasmacytoma and MALT lymphoma. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:526-532)

• 出版日期2012-4