Molecular Phylogeny and Functional Genomics of beta-Galactoside alpha 2,6-Sialyltransferases That Explain Ubiquitous Expression of st6gal1 Gene in Amniotes

作者：Petit Daniel; Mir Anne Marie; Petit Jean Michel; Thisse Christine; Delannoy Philippe; Oriol Rafael; Thisse Bernard; Harduin Lepers Anne^*

来源：Journal of Biological Chemistry, 2010, 285(49): 38399-38414.

DOI：10.1074/jbc.M110.163931

Sialyltransferases are key enzymes in the biosynthesis of sialoglycoconjugates that catalyze the transfer of sialic residue from its activated form to an oligosaccharidic acceptor. beta-Galactoside alpha 2,6-sialyltransferases ST6Gal I and ST6Gal II are the two unique members of the ST6Gal family described in higher vertebrates. The availability of genome sequences enabled the identification of more distantly related invertebrates' st6gal gene sequences and allowed us to propose a scenario of their evolution. Using a phylogenomic approach, we present further evidence of an accelerated evolution of the st6gal1 genes both in their genomic regulatory sequences and in their coding sequence in reptiles, birds, and mammals known as amniotes, whereas st6gal2 genes conserve an ancestral profile of expression throughout vertebrate evolution.

• 出版日期2010-12-3