Acute inhalational metallic nickel poisoning

作者：Mei Yong; Zhang Jinsong; Chen Xufeng; Zhang Gang; Sun Kai; Sun Hao; Liu Xia; Shen Bin

来源：中华急诊医学杂志, 2016, 25(12).

DOI：10.3760/cma.j.issn.1671-0282.2016.12.013

• Acute
• Metallic nickel
• Inhalational
• Poisoning
• Nickel concentration
• Acute respiratory distress syndrome
• Mechanical ventilation
• Glucocorticoid
• Chelation therapy

Objective To investigate the clinical characteristics of acute inhalational metallic nickel poisoning and its treatment effect.Methods Data including epidemiology,clinical features,laboratory tests,imaging examinations,therapy protocol as well as prognosis were collected and analyzed.Results Thoracic CT scan of all patients demonstrated as bilateral diffuse infiltration.Nickel concentration in both blood and urine were high in all patients and the concentration was positively associated with poisoning severity.All 4 patients received glucocorticoid treatment,2 of whom with acute respiratory distress syndrome were admitted to ICU to initiate mechanical ventilation and were given sodium dimercaptopropanesulfonate.All patients survived to hospital discharge.Conclusions Acute inhalational metallic nickel poisoning is uncommon and early symptoms are inconclusive.The blood and urine nickel concentration is helpful to judge the severity of the disease.Pulmonary diffuse infiltration is the main clinical feature.Glucocorticoid,chelation therapy as well as symptomatic treatment are effective therapies to relief disease severity.

• 出版日期2016
• 单位南京医科大学