Mineral concentration dependent modulation of mechanical properties of bone-inspired bionanocomposite scaffold

作者：Biswas Abhijit^*; Ovaert Timothy C; Slaboch Constance; Zhao He; Bayer Ilker S; Biris Alexandru S; Wang Tao

来源：Applied Physics Letters, 2011, 99(1): 013702.

DOI：10.1063/1.3607283

We demonstrate tunable mechanical properties of bone-inspired bionanocomposite scaffolds while maintaining the required viscoelasticity. Mechanical properties such as hardness and elastic modulus of the bionanocomposite scaffolds were controlled by varying mineral concentrations of the bioscaffold. In particular, higher calcium and oxygen contents in the bioscaffold resulted in a significant enhancement in hardness and modulus of the bionanocomposite. Moreover, the phosphorous content appeared to be a determining factor in the hardness and mechanical properties of the bionanocomposites. These results open up the possibility of designing new engineered biocompatible nanoscaffolds with desired and tunable biomimetic functions and biomechanical properties with significant potential for advanced bone tissue engineering platforms and bone substitutes.

• 出版日期2011-7-4