科研之友
微信
新浪微博
Facebook
分享链接
摘要
Bipolar disorder (BD) is a debilitating mental disorder. However, there are no biomarkers available to support objective laboratory testing for this disorder. Here, a nuclear magnetic resonance spectroscopy-based metabonomic method was used to characterize the urinary metabolic profiling of BD subjects and healthy controls in order to identify and validate urinary metabolite biomarkers for BD. Four metabolites, alpha-hydroxybutyrate, choline, isobutyrate, and N-methylnicotinamide, were defined as biomarkers. A combined panel of these four urinary metabolites could effectively discriminate between BD subjects and healthy controls, achieving an area under the receiver operating characteristic curve (AUC) of 0.89 in a training set (n = 60 BD patients and n = 62 controls). Moreover, this urinary biomarker panel was capable of discriminating blinded test samples (n = 26 BD patients and n = 34 controls) with an AUC of 0.86. These findings suggest that a urine-based laboratory test using these biomarkers may be useful in the diagnosis of BD.
- 出版日期2013-8
- 单位重庆医科大学; 中国人民解放军总医院
