Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children

作者：Hales Belinda J^*; Chai Lee Ying; Elliot Claire E; Pearce Leigh J; Zhang Guicheng; Heinrich Tatjana K; Smith Wendy Anne; Kusel Merci M; Holt Patrick G; Sly Peter D; Thomas Wayne R

来源：Thorax, 2012, 67(4): 321-327.

DOI：10.1136/thoraxjnl-2011-200650

Background Infants who develop house dust mite (HDM) allergy and HDM-sensitised children with severe persistent asthma have low antibody responses to the P6 antigen of Haemophilus influenzae. %26lt;br%26gt;Objective To measure the development of antibody to two ubiquitous bacteria of the respiratory mucosa in a prospective birth cohort at high risk of allergic disease and to assess which responses are associated with asthma and atopy. %26lt;br%26gt;Methods IgG1 and IgG4 antibody to H influenzae (P4 and P6) and Streptoccocus pneumoniae (PspA and PspC) surface antigens was measured in yearly blood samples of children aged 1-5 years. IgE to the P6 antigen was examined for the 5-year group. The children were stratified based on HDM sensitisation and asthma at 5 years of age. %26lt;br%26gt;Results HDM-sensitised children had lower IgG1 antibody titres to the bacterial antigens, and early responses (%26lt;3 years and before the development of HDM sensitisation and asthma) corrected for multiple antigens were significantly reduced for P4, P6 and PspC (p=0.008, p=0.004 and p=0.028, respectively). Similar associations with asthma were also found (p=0.008, p=0.004 and p=0.032 for P4, P6 and PspC, respectively). The IgG4 antibody titre and prevalence were similar in both HDM-sensitised and non-sensitised groups, but sensitised children had a slower downregulation of the IgG4 response. Children with asthma (27/145 at 5 years) had lower anti-P6 IgE responses (p%26lt;0.05). %26lt;br%26gt;Conclusions HDM-sensitised children have early defective antibody responses to bacteria that are associated with asthma. Surprisingly, antibacterial IgE was associated with a reduced risk for asthma.

• 出版日期2012-4