Complex Class 1 Integron Carrying qnrB62 and bla(VIM-2) in a Citrobacter freundii Clinical Isolate

作者：Lee Jae Jin; Kim Mi Na; Park Kwang Seung; Lee Jung Hun; Karim Asad Mustafa; Park Moonhee; Kim Ji Hwan; Lee Sang Hee^*

来源：Antimicrobial Agents and Chemotherapy, 2016, 60(11): 6937-6940.

DOI：10.1128/AAC.00614-16

The coexistence of qnrB62 and bla(VIM-2) was detected in a Citrobacter clinical isolate. The reduced fluoroquinolone susceptibility is attributable to qnrB62, mutations of quinolone-resistance-determining regions, and an efflux pump or pumps. The genetic context surrounding chromosomal qnrB62 was a novel complex class 1 integron (In1184:: ISCR1:: qnrB62) containing a unique gene array (bla(VIM-2)-aacA4 '=-8-gucD). An 18-nucleotide deletion at the 3' end of the pspA gene [pspA(Delta 18)], upstream of qnrB62, and an inverted repeat region (IRR2) were detected in In1184:: ISCR1:: qnrB62, indicating past transposition events.

• 出版日期2016-11