Muscle strength and body composition during the transition phase in patients treated with recombinant GH to final height

作者：Modesto Marilza de Jesus; Amer Nadia Mohamad; Erichsen Oscar; Hernandez Sara; dos Santos Claudia Duarte; Ramires de Carvalho Julienne Angela; Pereira Rosana Marques; Franca Suzana Nesi; De lacerda Luiz^*

来源：Journal of Pediatric Endocrinology & Metabolism, 2014, 27(9-10): 813-820.

DOI：10.1515/jpem-2013-0317

• body composition
• growth hormone deficiency
• muscle strength
• recombinant growth hormone
• transition phase

We assessed body composition and muscle strength during the transition phase in 18 growth hormone (GH) deficient males treated with recombinant GH to final height and 18 controls. According to peak-stimulated GH and basal insulin-like growth factor-1 (IGF-1) during the transition phase, patients were subdivided into GH deficient (GHD-TP, n=9) and GH sufficient (GHSTP, n=9) groups. Assessments included lean and fat body mass and bone mineral density (BMD), all measured by dual-energy X-ray absorptiometry, and dynamic knee muscle strength, assessed by isokinetic dynamometer. Total body and lumbar spine BMD and muscle strength were lower in GHD-TP patients when compared with GHS-TP and controls (all p<0.05), whereas lean and fat body mass were lower in both GHD-TP and GHS-TP patients when compared with controls (p<0.05). These findings suggest that administration of recombinant GH to final height is not sufficient to provide normal body composition and muscle strength in young male patients with GH deficiency.

• 出版日期2014-9