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摘要
Purpose: This observational study investigated the association between serum osteocalcin level and blood pressure in a Chinese population.Materials and methods: A total of 2241 subjects (909 men and 1,332 women; age, 24-78 years) from Shanghai communities were recruited. Subjects were divided into non-hypertensive and hypertensive groups according to diagnosis of hypertension based on the 1999 World Health Organization-International Society of Hypertension Guidelines. Serum osteocalcin levels were measured using an electrochemiluminescence immunoassay.Results: Men in the hypertensive group showed lower serum osteocalcin level compared with those in the non-hypertensive group, [16.37 (13.34-20.11) ng/mL versus 17.01 (14.23-20.79) ng/mL, p=.039]. No difference in serum osteocalcin level was found between the two groups of women (p=.675). An inverse association was observed between serum osteocalcin level and systolic blood pressure (SBP) in men (p=.004), but serum osteocalcin level was not associated with diastolic blood pressure (DBP) in men (p=.472). No associations were detected between serum osteocalcin level and SBP or DBP in women (SBP: p=.108; DBP: p=.575). A multiple stepwise regression analysis showed an inverse association between serum osteocalcin level and SBP in men after adjusting for age, smoking status, family history of hypertension, and lipid and C-reactive protein levels (standardized =-0.074, p=.023), but the association disappeared after adjustment for body mass index, waist circumference, blood glucose, and homeostasis model assessment of insulin resistance (p=.327).Conclusions: Serum osteocalcin level was not independently associated with blood pressure in a Chinese population.
- 出版日期2018
- 单位上海市临床检验中心; 上海交通大学
