Assessment of liver fibrosis in chronic hepatitis B using acoustic structure quantification: quantitative morphological ultrasound

作者：Huang, Yang; Wang, Zhu; Liao, Bing; Liang, Jin-Yu; Zhou, Lu-Yao; Wang, Fen; Li, Wei; Liu, Jin-Ya; Xie, Xiao-Yan; Lu, Ming-De; Liu, Guang-Jian^*; Wang, Wei^*

来源：European Radiology, 2016, 26(7): 2344-2351.

DOI：10.1007/s00330-015-4056-x

• Liver fibrosis
• Hepatitis B
• Transient elastography
• Acoustic structure quantification
• Focal disturbance ratio

Objectives To prospectively investigate the usefulness of acoustic structure quantification (ASQ) for noninvasive assessment of liver fibrosis in patients with chronic hepatitis B (CHB). @@@ Consecutive patients with CHB scheduled for liver biopsy or partial liver resection underwent standardized ASQ examinations. The ASQ parameter, named focal disturbance (FD) ratio, were compared with METAVIR scores. The analysis was based on receiver operating characteristic (ROC) curves and multiple regression analysis. @@@ A total of 114 patients were enrolled in the final analysis. The area under the ROC curve for the FD ratio was 0.84 for significant fibrosis (a parts per thousand yen F2), 0.86 for severe fibrosis (a parts per thousand yen F3), and 0.83 for cirrhosis (= F4). The optimal cutoff values for the FD ratio were 0.25, 0.30 and 0.50 for fibrosis stages a parts per thousand yenaEuro parts per thousand F2, a parts per thousand yen F3 and = F4, respectively. The prevalence of a difference of at least two stages between the FD ratio and the histological stage was 12.3 % (14 of 114). The fibrosis stage (P < 0.001), degree of steatosis (P < 0.001) were independent factors associated with the FD ratio. @@@ FD ratio should be an effective noninvasive imaging biomarker for the assessment of liver fibrosis in patients with CHB. @@@ Focal disturbance (FD) ratio increased with the increasing histological fibrosis stages. @@@ FD ratio showed promising diagnostic accuracy in assessing liver fibrosis. @@@ Degree of fibrosis and steatosis were independent factors associated with FD ratio.

• 出版日期2016-7
• 单位中山大学