An outbreak of aseptic meningitis caused by a distinct lineage of coxsackievirus B5 in China

作者：Liu Nan; Jia Leili; Yin Jiye; Wu Zhihao; Wang Zhongqiang; Li Peng; Hao Rongzhang; Wang Ligui; Wang Yong; Qiu Shaofu^*; Song Hongbin

来源：International Journal of Infectious Diseases, 2014, 23: 101-104.

DOI：10.1016/j.ijid.2014.02.005

• Outbreak
• Aseptic meningitis
• Coxsackievirus B5
• Genetically distinct
• Substitution

In 2009, an outbreak of aseptic meningitis caused by coxsackievirus B5 (CVB5) occurred in China. Epidemiological investigations of this outbreak revealed that the proportion of severe cases (14/43, 33%) was higher than in other outbreaks associated with CVB5 in China. Phylogenetic analysis of the entire VP1 sequences demonstrated that the CVB5 isolates from the severe cases form a distinct lineage belonging to genogroup E with the Shandong isolates of 2009. A substitution of serine (S) to asparagine (N) at amino acid 95 in the VP1 region may be a major virulence determinant for the virus. Our findings suggest that this new lineage of CVB5 is circulating in China. Further genetic studies are needed in order to gain a better insight into the genetic variability of CVB5 isolates and the relationship with pathogenicity.

• 出版日期2014-6
• 单位中国人民解放军军事医学科学院