Vitamin D and diabetes: Its importance for beta cell and immune function

作者：Wolden Kirk Heidi; Overbergh Lut^*; Christesen Henrik Thybo; Brusgaard Klaus; Mathieu Chantal

来源：Molecular and Cellular Endocrinology, 2011, 347(1-2): 106-120.

DOI：10.1016/j.mce.2011.08.016

• Beta cell
• Vitamin D
• Diabetes
• Immune system
• Insulin secretion
• Apoptosis

Experimental evidence indicates that vitamin D may play a role in the defense against type 1 diabetes (T1D) as well as type 2 diabetes (T2D). Epidemiological data have established a link between vitamin D deficiency and an increased incidence of both T1D and T2D, whereas early and long-term vitamin D supplementation may decrease the risk of these disorders. The protective effects of vitamin D are mediated through the regulation of several components such as the immune system and calcium homeostasis. However, an increasing amount of evidence suggests that vitamin D also affects beta cells directly thereby rendering them more resistant to the types of cellular stress encountered during T1D and T2D. This review evaluates the role of vitamin D signaling in the pathogenesis of T1D and T2D with a special emphasis on the direct effects of vitamin D on pancreatic beta cells.

• 出版日期2011-12-5